Synthesis and absolute configuration of natural gregatin B.

Total synthesis and absolute configuration of nocardioazine B.

The first total synthesis of the indole alkaloid nocardioazine B was accomplished in 10 steps with an overall yield of 11.8%, establishing the absolute stereochemistry of the natural product.

Absolute configuration of fibaruretin B

The title furan-oditerpenoid, known as fibaruretin B (systematic name: 2β,3α-dihy-droxy-2,3,7,8α-tetra-hydro-penianthic acid lactone), C(20)H(24)O(7), was isolated from the roots of Arcangelisia flava. The absolute configurations at positions 2, 3, 4, 4a, 7, 9, 10a and 10b of fibaruretin B are S, R, S, R, S, S, S and S, respectively. In the crystal structure, the mol-ecules are linked into infi...

Total synthesis of auripyrones A and B and determination of the absolute configuration of auripyrone B.

Compounds containing the g-pyrone functional group have been isolated from marine animals (Figure 1). These compounds show valuable biological activities: for example, peroniatriols I (1) and II (2) exhibited significant cytotoxicity against L1210 cells. Also, vallartanone B (3) and onchidione (4) are chemical defense compounds of mollusks. Therefore, the development of a method to synthesize g...

Optical rotatory dispersion and absolute configuration. V. The absolute configuration of natural plasmalogen.

PLAWALOGENS are a group of aldehydogenic substances widely distributed in nature in both the animal and plant kingdom. 4 Their chemical structure is that of a c&l(alk-l’enyl) ether of a 2-acyl-3glycerylphosphate (I) where R” may be derived from choline, ethanolamine or serine. Hydrogenation and acid hydrolysis8 yielded chimyl and batyl alcohols (IIa and IIb), while enzymic hydrolysis followed b...

Total synthesis and absolute configuration of macrocidin A, a cyclophane tetramic acid natural product.